Complexities in the medical management of hypoglycaemia due to congenital hyperinsulinism
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چکیده
منابع مشابه
Diagnosis and management of hypoglycaemia due to pancreatic insulin-secreting neoplasia in a German shepherd dog
A 7-year-old castrated male German shepherd dog was presented with a 10-day history of intermittent lethargy, weakness and episodic seizures. Laboratory findings after admission revealed hypoglycaemia and hyperinsulinaemia. Provisional diagnosis of insulinoma was made based on the presence of concurrent hypoglycaemia and elevated insulin level. In exploratory laparotomy a small nodular mass was...
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15 صفحه اول[Congenital hyperinsulinism].
In the last five years, our knowledge about the heterogenous syndrome of congenital hyperinsulinism (HI) has expanded explosively. HI may be familiar or sporadic, mild or severe, transitory or persistent, and histologically focal or diffuse. At least 63 disease-causing mutations have been found in the genes for the beta cell's ATP-dependent potassium channel, whose elements are the sulphonylure...
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Antidepressant drugs are reported to cause alterations in blood glucose homeostasis in adults with diabetes mellitus. We report a patient with persistent congenital hyperinsulinism (CHI) who developed recurrent hypoglycaemia following fluoxetine therapy. This 15-year-old girl was initially managed with diazoxide therapy. She developed troublesome hypertrichosis, which affected her quality of li...
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Laboratory investigations revealed hemoglobin 14.6 g/dL, total leukocyte count 12X109/L, and platelet count 290X109/L. C-reactive protein (CRP) was negative. During the hospital stay, the infant had repeated generalized and focal clonic seizures during documented hypoglycemic episodes requiring glucose infusion rate (GIR) up to 14 mg/kg/min. There was no ketosis, hyperammonemia, or lactic acido...
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ژورنال
عنوان ژورنال: Clinical Endocrinology
سال: 2020
ISSN: 0300-0664,1365-2265
DOI: 10.1111/cen.14152